Roitt's Essential Immunology

Thirteenth Edition

Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt

Single Best Answer Questions

Chapter 5, Question 1.

1. The single best unique description of the interaction of the alpha-beta T-cell receptor with peptide-MHC is that it:

A Involves non-covalent forces

B Results in T-cell activation

C Requires the peptide to be presented by MHC class I

D Involves CDR (complementarity-determining region) binding to both peptide and MHC

E Is of relatively low affinity compared with antibody binding to native antigen